Is CBD oil bad for glaucoma
Glaucoma: CBD increases eye pressure
In previous studies, there were indications that in addition to THC, other cannabinoids such as CBD and CBN could possibly lower the intraocular pressure in glaucoma (Leafly reported). In addition, eye drops based on THC and / or CBD are already available abroad.
However, Indiana University researchers have now shown their study that an essential chemical component of the cannabis plant appears to worsen the primary background of the disease, namely the increase in pressure in the eye. It is cannabidiol (CBD), a non-psychoactive ingredient in cannabis that is increasingly being marketed to consumers in products such as oil or creams.
“This study raises important questions about the relationship between the main components of cannabis and their effects on the eye. This also suggests the need to learn more about the possible undesirable side effects of CBD. Especially because of its use in children, ”explained the scientist Alex Straiker.
Glaucoma and CBD: Study Results
After laboratory mice were given CBD, the researchers found that CBD caused an 18 percent increase in pressure in the eye for at least four hours after use.
The psychoactive cannabinoid tetrahydrocannabinol (THC), on the other hand, lowered eye pressure. The researchers also report that the use of CBD in combination with THC blocks this effect. Male mice experienced a drop in intraocular pressure of almost 30 percent eight hours after exposure to THC alone. After four hours, a lower pressure drop of 22 percent was observed.
In contrast, the effect was weaker in female mice. This group experienced a pressure drop of only 17 percent after four hours. After eight hours there was no measurable difference in intraocular pressure.
The results suggest that women may be less affected by THC. Although it is not clear whether this concerns the psychoactive effects of the substance.
“This difference between men and women - and the fact that CBD appears to increase intraocular pressure, the main risk factor for glaucoma, are both important aspects of this study. It is also noteworthy that CBD appears to actively combat the positive effects of THC, ”explained Straiker.
Researchers identify specific neuroreceptors
By comparing the effects of these substances in mice without specific neuroreceptors affected by THC and CBD, the researchers were also able to identify the two specific neuroreceptors CB1 and GPR18, through which the first substance lowered the pressure in the eye.
“There were studies over 45 years ago that found evidence that THC reduced pressure in the eye, but until this study, no one had identified the specific neuroreceptors involved in the process. These results could have important implications for future research on the use of cannabis as a therapy for intraocular pressure, ”concluded Straiker.
It should be interesting how this study affects cannabis eye drops (e.g. CANASOL) that are already available. The same goes for CBD eye drops, which are available in the United States, for example. We'll stay tuned and report.
Note: In this article we report on prescription CBD or cannabidiol. This article makes no suggestion as to the possible purpose. Promises of use are left to the pharmacists.
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