You can overdose on clobetasol propionate


Clobetasol propionateDrug groupsTopical glucocorticoids: Clobetasol propionate is an anti-inflammatory, antipruritic, immunosuppressive and antiallergic active ingredient from the group of highly effective glucocorticoids for the external and short-term treatment of skin diseases. The medicines are usually applied thinly once or twice a day. The most common adverse effects include local skin reactions. Improper and overdosed treatment should be avoided because skin changes and systemic side effects of cortisone can occur.

synonymous: Clobetasoli propionas, Clobetasoli-17-propionas, Clobetasol-17-propionate

Products

Clobetasol propionate is available as a cream, ointment, foam, shampoo and scalp application (Dermovate®, Clobex®, Clarelux®). It has been approved in Switzerland since 1976.

Structure and properties

Clobetasol propionate (C.25H32ClFO5, Mr = 466.97 g / mol) is the ester of Clobetasol with propionic acid. It is a derivative of prednisolone. Clobetasol propionate is a white, crystalline powder that is insoluble in water.

Effects

Clobetasol propionate (ATC D07AD01) has anti-inflammatory, antipruritic, immunosuppressive, vasoconstricting and antiallergic properties. Clobetasol propionate is one of the very effective topical glucocorticoids (strength class IV). The effects are based on the binding to intracellular glucocorticoid receptors in the cytoplasm of the cells. The resulting complex interacts with the DNA.

Mechanism of action of the glucocorticoids, click to enlarge. Illustration © PharmaWiki

Indications

For the treatment of skin conditions that respond to topical glucocorticoids.

The liquid dosage forms are used to treat eczema and psoriasis of the scalp.

dosage

According to the specialist information. The medicines are usually applied thinly once or twice a day. Dermocorticoids are not suitable for uninterrupted long-term treatment.

Contraindications

The complete precautionary measures can be found in the medicinal product information sheet.

Interactions

CYP3A4 inhibitors inhibit the metabolism of clobetasol propionate and can lead to increased systemic exposure.

unwanted effects

The most common possible adverse effects include local skin reactions such as burning sensation, pain and itching. Improper and overdosed use can lead to skin changes such as skin thinning, striae and telangiectasias as well as systemic glucocorticoid side effects.

see also

Topical glucocorticoids, clobetasol butyrate

literature
  • Pharmaceutical product information (CH, D, UK, USA)
  • Feldman S.R., Yentzer B.A. Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations. Am J Clin Dermatol, 2009, 10 (6), 397-406 Pubmed
  • Menter M.A., Caveney S.W., Gottschalk R.W. Impact of clobetasol propionate 0.05% spray on health-related quality of life in patients with plaque psoriasis. J Drugs Dermatol, 2012, 11 (11), 1348-54 Pubmed
  • Pels R., Sterry W., Lademann J. Clobetasol propionate - where, when, why? Drugs Today (Barc), 2008, 44 (7), 547-57 Pubmed
  • Reid D.C., Kimball A.B. Clobetasol propionate foam in the treatment of psoriasis. Expert Opin Pharmacother, 2005, 6 (10), 1735-40 Pubmed
author

Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.

additional Information
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This article was last changed on 5/17/2020.
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