What are GABA receptors
The Gamma (y) aminobutyric acid (short: GABA) is the most important inhibitory neurotransmitter in the central nervous system of mammals. In contrast to excitatory neurotransmitters such as glutamate, adrenaline or dopamine, GABA reduces the excitability of nerve cells.
As soon as a GABA molecule binds in a specific GABA receptor, ion channels open which are responsible for chloride ions (Cl-) are permeable. As a result, the influx of negatively charged ions leads to hyperpolarization of the postsynaptic membrane (IPSP) and thus to inhibition of excitation. This principle applies at least to GABAaReceptors. Depending on the type of GABA receptor, there are differences in how the inhibition works.
GABA is obtained in the human organism from the non-essential amino acid glutamic acid. Glutamic acid (C.5H9NO4) is converted by glutamate decarboxylase in both the brain and the pancreas to GABA (C.4H9NO2) decarboxylated. During this process, the enzyme glutamate decarboxylase splits a carbon dioxide molecule (CO2) from the amino acid.
In the brain, GABA is the most common neurotransmitter with a share of about 1/3. It is therefore not surprising that sleep is essentially controlled by the inhibitory function of the GABAergic neurons. Medicines such as narcotics or benzodiazepines to induce sleep or to reduce anxiety also bind to the y-aminobutyric acid receptors and thus inhibit arousal.
In the pancreas, the other place in the body where GABA transmitters and receptors are found in large quantities, γ-aminobutyric acid helps control blood sugar levels. There, GABA controls the inhibition of the secretion of the hormone glucagon, which is responsible for the rise in blood sugar levels.
- What is a hip hop cipher
- Which artist sang the song Piano Man
- How do you rate the food
- What is the value of cos 1710
- Why do some people dislike ASMR videos
- How do wingless airplanes generate lift
- Is killing a person a perfect crime?
- How do I pronounce Hyllinge in Swedish
- Pierre de Fermat was usually right
- Who pays for the UN
- What do you call subways
- Will Russia win the Cold War?
- How do you not motivate people
- States should be responsible for education
- What is a fennec
- What if you kill a fly
- Are Presbyterians and Calvinists the same
- Why can't India be like Israel?
- Why is the US saving less?
- How do teachers deal with disappointed parents?
- What's your grandma's favorite song
- What did you think of again today?
- Can you tell me about the family pension?
- Is there an internship from home?